Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

Clinical and preclinical studies indicate that early postnatal exposure to anesthetics can lead to lasting deficits in learning and other cognitive processes. The mechanism underlying this phenomenon has not been clarified and there is no treatment currently available. Recent evidence suggests that...

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Detalles Bibliográficos
Autores principales: Kang, Eunchai, Jiang, Danye, Ryu, Yun Kyoung, Lim, Sanghee, Kwak, Minhye, Gray, Christy D., Xu, Michael, Choi, Jun H., Junn, Sue, Kim, Jieun, Xu, Jing, Schaefer, Michele, Johns, Roger A., Song, Hongjun, Ming, Guo-Li, Mintz, C. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500005/
https://www.ncbi.nlm.nih.gov/pubmed/28683067
http://dx.doi.org/10.1371/journal.pbio.2001246

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