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Association between formaldehyde exposure and miscarriage in Chinese women

The aim of this study was to assess whether higher plasma formaldehyde concentration existed in women diagnosed with miscarriage and whether it contributed to higher risk of miscarriage in Chinese women. A case-control study was conducted in 118 women with a diagnosed miscarriage at the first trimes...

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Autores principales: Xu, Wenjing, Zhang, Weiqiang, Zhang, Xuezhen, Dong, Taowei, Zeng, Huiqian, Fan, Qiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500027/
https://www.ncbi.nlm.nih.gov/pubmed/28658105
http://dx.doi.org/10.1097/MD.0000000000007146
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author Xu, Wenjing
Zhang, Weiqiang
Zhang, Xuezhen
Dong, Taowei
Zeng, Huiqian
Fan, Qiyun
author_facet Xu, Wenjing
Zhang, Weiqiang
Zhang, Xuezhen
Dong, Taowei
Zeng, Huiqian
Fan, Qiyun
author_sort Xu, Wenjing
collection PubMed
description The aim of this study was to assess whether higher plasma formaldehyde concentration existed in women diagnosed with miscarriage and whether it contributed to higher risk of miscarriage in Chinese women. A case-control study was conducted in 118 women with a diagnosed miscarriage at the first trimester and 191 healthy women who delivered at term. Plasma levels of formaldehyde were measured by gas chromatography in conjunction with mass spectrometry after derivatization of the formaldehyde to the pentafluorophenylhydrazone and characteristics of the subjects including age, education level, occupation, family income, home decoration status, and exposure to second-hand smoke were recorded. Logistic regression analyses were performed to investigate the relationship between miscarriage and levels of formaldehyde. Women with miscarriage were comparable to controls in terms of age, education level, occupation, family income, and home decoration status. They were, however, more likely to be exposed to second-hand smoke. Plasma levels of formaldehyde were significantly higher in women with miscarriage (0.0944 ± 0.0105 vs. 0.0239 ± 0.0032 μg/mL, P < .001). Multivariate logistic regression showed that higher level of formaldehyde (odds ratio [OR]: 8.06, 95% confidence interval [CI]: 4.96–13.09) and exposure to second-hand smoke (OR: 3.60, 95% CI: 1.58–8.20) were independently and significantly associated with higher risk of miscarriage. Plasma levels of formaldehyde were significantly higher in women who were diagnosed with miscarriage than those who delivered at term and higher levels of formaldehyde was an independent risk factor for miscarriage, with higher levels being associated with higher risk of miscarriage.
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spelling pubmed-55000272017-07-17 Association between formaldehyde exposure and miscarriage in Chinese women Xu, Wenjing Zhang, Weiqiang Zhang, Xuezhen Dong, Taowei Zeng, Huiqian Fan, Qiyun Medicine (Baltimore) 5600 The aim of this study was to assess whether higher plasma formaldehyde concentration existed in women diagnosed with miscarriage and whether it contributed to higher risk of miscarriage in Chinese women. A case-control study was conducted in 118 women with a diagnosed miscarriage at the first trimester and 191 healthy women who delivered at term. Plasma levels of formaldehyde were measured by gas chromatography in conjunction with mass spectrometry after derivatization of the formaldehyde to the pentafluorophenylhydrazone and characteristics of the subjects including age, education level, occupation, family income, home decoration status, and exposure to second-hand smoke were recorded. Logistic regression analyses were performed to investigate the relationship between miscarriage and levels of formaldehyde. Women with miscarriage were comparable to controls in terms of age, education level, occupation, family income, and home decoration status. They were, however, more likely to be exposed to second-hand smoke. Plasma levels of formaldehyde were significantly higher in women with miscarriage (0.0944 ± 0.0105 vs. 0.0239 ± 0.0032 μg/mL, P < .001). Multivariate logistic regression showed that higher level of formaldehyde (odds ratio [OR]: 8.06, 95% confidence interval [CI]: 4.96–13.09) and exposure to second-hand smoke (OR: 3.60, 95% CI: 1.58–8.20) were independently and significantly associated with higher risk of miscarriage. Plasma levels of formaldehyde were significantly higher in women who were diagnosed with miscarriage than those who delivered at term and higher levels of formaldehyde was an independent risk factor for miscarriage, with higher levels being associated with higher risk of miscarriage. Wolters Kluwer Health 2017-06-30 /pmc/articles/PMC5500027/ /pubmed/28658105 http://dx.doi.org/10.1097/MD.0000000000007146 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5600
Xu, Wenjing
Zhang, Weiqiang
Zhang, Xuezhen
Dong, Taowei
Zeng, Huiqian
Fan, Qiyun
Association between formaldehyde exposure and miscarriage in Chinese women
title Association between formaldehyde exposure and miscarriage in Chinese women
title_full Association between formaldehyde exposure and miscarriage in Chinese women
title_fullStr Association between formaldehyde exposure and miscarriage in Chinese women
title_full_unstemmed Association between formaldehyde exposure and miscarriage in Chinese women
title_short Association between formaldehyde exposure and miscarriage in Chinese women
title_sort association between formaldehyde exposure and miscarriage in chinese women
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500027/
https://www.ncbi.nlm.nih.gov/pubmed/28658105
http://dx.doi.org/10.1097/MD.0000000000007146
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