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Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol
INTRODUCTION: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-fluorodeoxyglucose positron emission tomography/c...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500053/ https://www.ncbi.nlm.nih.gov/pubmed/28658131 http://dx.doi.org/10.1097/MD.0000000000007297 |
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author | Emamifar, Amir Hess, Søren Gerke, Oke Hermann, Anne Pernille Laustrup, Helle Hansen, Per Syrak Thye-Rønn, Peter Marcussen, Niels Svendstrup, Frank Gildberg-Mortensen, Rannveig Bang, Jacob Christian Farahani, Ziba Ahangarani Chrysidis, Stavros Toftegaard, Pia Andreasen, Rikke Asmussen le Greves, Sebastian Andersen, Hanne Randi Olsen, Rudolf Nezlo Hansen, Inger Marie Jensen |
author_facet | Emamifar, Amir Hess, Søren Gerke, Oke Hermann, Anne Pernille Laustrup, Helle Hansen, Per Syrak Thye-Rønn, Peter Marcussen, Niels Svendstrup, Frank Gildberg-Mortensen, Rannveig Bang, Jacob Christian Farahani, Ziba Ahangarani Chrysidis, Stavros Toftegaard, Pia Andreasen, Rikke Asmussen le Greves, Sebastian Andersen, Hanne Randi Olsen, Rudolf Nezlo Hansen, Inger Marie Jensen |
author_sort | Emamifar, Amir |
collection | PubMed |
description | INTRODUCTION: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to assess global disease activity in inflammatory diseases. 18F-FDG PET/CT may lead to the diagnosis at an earlier stage than conventional imaging and may also assess response to therapy. With respect to the management of PMR/GCA, there are 3 significant areas of concern as follows: vasculitis process/vascular stiffness, malignancy, and osteoporosis. METHODS AND ANALYSIS: All patients with suspected PMR/GCR referred to the Rheumatology section of Medicine Department at Svendborg Hospital, Denmark. The 4 separate studies in the current protocol focus on: the association of clinical picture of PMR/GCA with PET findings; the validity of 18F-FDG PET/CT scan for diagnosis of PMR/GCA compared with temporal artery biopsy; the prevalence of newly diagnosed malignancies in patients with PMR/GCA, or PMR-like syndrome, with the focus on diagnostic accuracy of 18F-FDG PET/CT scan compared with conventional workup (ie, chest X-ray/abdominal ultrasound); and the impact of disease process, and also steroid treatment on bone mineral density, body composition, and vasculitis/vascular stiffness in PMR/GCA patients. ETHICS AND DISSEMINATION: The study has been approved by the Regional Ethics Committee of the Region of Southern Denmark (identification number: S-20160098) and Danish Data Protection Agency (J.nr 16/40522). Results of the study will be disseminated via publications in peer-reviewed journals, and presentation at national and international conferences. |
format | Online Article Text |
id | pubmed-5500053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-55000532017-07-17 Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol Emamifar, Amir Hess, Søren Gerke, Oke Hermann, Anne Pernille Laustrup, Helle Hansen, Per Syrak Thye-Rønn, Peter Marcussen, Niels Svendstrup, Frank Gildberg-Mortensen, Rannveig Bang, Jacob Christian Farahani, Ziba Ahangarani Chrysidis, Stavros Toftegaard, Pia Andreasen, Rikke Asmussen le Greves, Sebastian Andersen, Hanne Randi Olsen, Rudolf Nezlo Hansen, Inger Marie Jensen Medicine (Baltimore) 6900 INTRODUCTION: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to assess global disease activity in inflammatory diseases. 18F-FDG PET/CT may lead to the diagnosis at an earlier stage than conventional imaging and may also assess response to therapy. With respect to the management of PMR/GCA, there are 3 significant areas of concern as follows: vasculitis process/vascular stiffness, malignancy, and osteoporosis. METHODS AND ANALYSIS: All patients with suspected PMR/GCR referred to the Rheumatology section of Medicine Department at Svendborg Hospital, Denmark. The 4 separate studies in the current protocol focus on: the association of clinical picture of PMR/GCA with PET findings; the validity of 18F-FDG PET/CT scan for diagnosis of PMR/GCA compared with temporal artery biopsy; the prevalence of newly diagnosed malignancies in patients with PMR/GCA, or PMR-like syndrome, with the focus on diagnostic accuracy of 18F-FDG PET/CT scan compared with conventional workup (ie, chest X-ray/abdominal ultrasound); and the impact of disease process, and also steroid treatment on bone mineral density, body composition, and vasculitis/vascular stiffness in PMR/GCA patients. ETHICS AND DISSEMINATION: The study has been approved by the Regional Ethics Committee of the Region of Southern Denmark (identification number: S-20160098) and Danish Data Protection Agency (J.nr 16/40522). Results of the study will be disseminated via publications in peer-reviewed journals, and presentation at national and international conferences. Wolters Kluwer Health 2017-06-30 /pmc/articles/PMC5500053/ /pubmed/28658131 http://dx.doi.org/10.1097/MD.0000000000007297 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 6900 Emamifar, Amir Hess, Søren Gerke, Oke Hermann, Anne Pernille Laustrup, Helle Hansen, Per Syrak Thye-Rønn, Peter Marcussen, Niels Svendstrup, Frank Gildberg-Mortensen, Rannveig Bang, Jacob Christian Farahani, Ziba Ahangarani Chrysidis, Stavros Toftegaard, Pia Andreasen, Rikke Asmussen le Greves, Sebastian Andersen, Hanne Randi Olsen, Rudolf Nezlo Hansen, Inger Marie Jensen Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol |
title | Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol |
title_full | Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol |
title_fullStr | Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol |
title_full_unstemmed | Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol |
title_short | Polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol |
title_sort | polymyalgia rheumatica and giant cell arteritis—three challenges—consequences of the vasculitis process, osteoporosis, and malignancy: a prospective cohort study protocol |
topic | 6900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500053/ https://www.ncbi.nlm.nih.gov/pubmed/28658131 http://dx.doi.org/10.1097/MD.0000000000007297 |
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