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Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience

BACKGROUND: The true incidence of gonadal germ cell tumors (GCTs) in children is unknown. Few studies have been published concerning about pediatric gonadal GCTs. The aim of this study is to review and analyze clinical data on the diagnosis and management of gonadal GCTs in children. METHODS: Betwee...

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Autores principales: Lin, Xiaokun, Wu, Dazhou, Zheng, Na, Xia, Qiongzhang, Han, Yijiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500093/
https://www.ncbi.nlm.nih.gov/pubmed/28658171
http://dx.doi.org/10.1097/MD.0000000000007386
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author Lin, Xiaokun
Wu, Dazhou
Zheng, Na
Xia, Qiongzhang
Han, Yijiang
author_facet Lin, Xiaokun
Wu, Dazhou
Zheng, Na
Xia, Qiongzhang
Han, Yijiang
author_sort Lin, Xiaokun
collection PubMed
description BACKGROUND: The true incidence of gonadal germ cell tumors (GCTs) in children is unknown. Few studies have been published concerning about pediatric gonadal GCTs. The aim of this study is to review and analyze clinical data on the diagnosis and management of gonadal GCTs in children. METHODS: Between 2005 and 2015, 127 pediatric patients (<14 years old) with gonadal GCTs admitted to our institute were reviewed. Clinical features, imaging and laboratory studies, surgical approaches, as well as pathological diagnoses were recorded. RESULTS: The series comprised 53 males with testicular GCTs and 74 females with ovarian GCTs. Their median age was 5.8 years old. Palpable mass was the main clinical manifestation of testicular GCTs, while abdominal pain and abdominal distention were the most frequent presenting symptoms of ovarian GCTs. Both computed tomography and magnetic resonance imaging showed a high diagnostic yield. AFP levels were elevated in most malignant GCTs, markedly elevated in yolk sac tumors. All patients were treated surgically. Mature teratoma was the most common type of benign GCTs, while yolk sac tumor was the most common type of malignant GCTs. CONCLUSION: Gonadal GCTs in children have various of pathological types, as well as clinical manifestations. Imaging and laboratory data could be useful for differentiation of malignant from benign tumors. Final diagnosis depends on pathology. Surgical excision of the gonadal GCTs is the prior option.
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spelling pubmed-55000932017-07-17 Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience Lin, Xiaokun Wu, Dazhou Zheng, Na Xia, Qiongzhang Han, Yijiang Medicine (Baltimore) 6200 BACKGROUND: The true incidence of gonadal germ cell tumors (GCTs) in children is unknown. Few studies have been published concerning about pediatric gonadal GCTs. The aim of this study is to review and analyze clinical data on the diagnosis and management of gonadal GCTs in children. METHODS: Between 2005 and 2015, 127 pediatric patients (<14 years old) with gonadal GCTs admitted to our institute were reviewed. Clinical features, imaging and laboratory studies, surgical approaches, as well as pathological diagnoses were recorded. RESULTS: The series comprised 53 males with testicular GCTs and 74 females with ovarian GCTs. Their median age was 5.8 years old. Palpable mass was the main clinical manifestation of testicular GCTs, while abdominal pain and abdominal distention were the most frequent presenting symptoms of ovarian GCTs. Both computed tomography and magnetic resonance imaging showed a high diagnostic yield. AFP levels were elevated in most malignant GCTs, markedly elevated in yolk sac tumors. All patients were treated surgically. Mature teratoma was the most common type of benign GCTs, while yolk sac tumor was the most common type of malignant GCTs. CONCLUSION: Gonadal GCTs in children have various of pathological types, as well as clinical manifestations. Imaging and laboratory data could be useful for differentiation of malignant from benign tumors. Final diagnosis depends on pathology. Surgical excision of the gonadal GCTs is the prior option. Wolters Kluwer Health 2017-06-30 /pmc/articles/PMC5500093/ /pubmed/28658171 http://dx.doi.org/10.1097/MD.0000000000007386 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 6200
Lin, Xiaokun
Wu, Dazhou
Zheng, Na
Xia, Qiongzhang
Han, Yijiang
Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience
title Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience
title_full Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience
title_fullStr Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience
title_full_unstemmed Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience
title_short Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience
title_sort gonadal germ cell tumors in children: a retrospective review of a 10-year single-center experience
topic 6200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500093/
https://www.ncbi.nlm.nih.gov/pubmed/28658171
http://dx.doi.org/10.1097/MD.0000000000007386
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