Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents

The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading “activation memories” between inhibitory sy...

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Detalles Bibliográficos
Autores principales: de Luca, Emanuela, Ravasenga, Tiziana, Petrini, Enrica Maria, Polenghi, Alice, Nieus, Thierry, Guazzi, Stefania, Barberis, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500312/
https://www.ncbi.nlm.nih.gov/pubmed/28683270
http://dx.doi.org/10.1016/j.neuron.2017.06.022
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author de Luca, Emanuela
Ravasenga, Tiziana
Petrini, Enrica Maria
Polenghi, Alice
Nieus, Thierry
Guazzi, Stefania
Barberis, Andrea
author_facet de Luca, Emanuela
Ravasenga, Tiziana
Petrini, Enrica Maria
Polenghi, Alice
Nieus, Thierry
Guazzi, Stefania
Barberis, Andrea
author_sort de Luca, Emanuela
collection PubMed
description The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading “activation memories” between inhibitory synapses. Glutamatergic activity limits this inter-synaptic diffusion by trapping GABAARs at excitatory synapses. This novel form of activity-dependent hetero-synaptic interplay is likely to modulate dendritic synaptic signaling.
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spelling pubmed-55003122017-07-19 Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents de Luca, Emanuela Ravasenga, Tiziana Petrini, Enrica Maria Polenghi, Alice Nieus, Thierry Guazzi, Stefania Barberis, Andrea Neuron Report The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading “activation memories” between inhibitory synapses. Glutamatergic activity limits this inter-synaptic diffusion by trapping GABAARs at excitatory synapses. This novel form of activity-dependent hetero-synaptic interplay is likely to modulate dendritic synaptic signaling. Cell Press 2017-07-05 /pmc/articles/PMC5500312/ /pubmed/28683270 http://dx.doi.org/10.1016/j.neuron.2017.06.022 Text en © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Report
de Luca, Emanuela
Ravasenga, Tiziana
Petrini, Enrica Maria
Polenghi, Alice
Nieus, Thierry
Guazzi, Stefania
Barberis, Andrea
Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents
title Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents
title_full Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents
title_fullStr Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents
title_full_unstemmed Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents
title_short Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents
title_sort inter-synaptic lateral diffusion of gabaa receptors shapes inhibitory synaptic currents
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500312/
https://www.ncbi.nlm.nih.gov/pubmed/28683270
http://dx.doi.org/10.1016/j.neuron.2017.06.022
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