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An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII

Coagulation Factor VIII is activated by an ordered limited thrombin proteolysis with different catalytic efficiency at three P1 Arginine residues: Arg(759)> Arg(1708)>Arg(391), indicating the flanking residues of the latter to be less optimal. This study aimed to investigate, in silico and in...

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Detalles Bibliográficos
Autores principales:	Pezeshkpoor, Behnaz, Schreck, Ursula, Biswas, Arijit, Driesen, Julia, Berkemeier, Ann-Cristin, Pavlova, Anna, Müller, Jens, Oldenburg, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500338/ https://www.ncbi.nlm.nih.gov/pubmed/28683085 http://dx.doi.org/10.1371/journal.pone.0180456

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