Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis

Regulation of capsid disassembly is crucial for efficient HIV-1 cDNA synthesis after entry, yet host factors involved in this process remain largely unknown. Here, we employ genetic screening of human T-cells to identify maternal embryonic leucine zipper kinase (MELK) as a host factor required for o...

Descripción completa

Detalles Bibliográficos
Autores principales: Takeuchi, Hiroaki, Saito, Hideki, Noda, Takeshi, Miyamoto, Tadashi, Yoshinaga, Tomokazu, Terahara, Kazutaka, Ishii, Hiroshi, Tsunetsugu-Yokota, Yasuko, Yamaoka, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500366/
https://www.ncbi.nlm.nih.gov/pubmed/28683086
http://dx.doi.org/10.1371/journal.ppat.1006441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500366/
https://www.ncbi.nlm.nih.gov/pubmed/28683086
http://dx.doi.org/10.1371/journal.ppat.1006441

Ejemplares similares