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Controllable Microfluidic Production of Drug-Loaded PLGA Nanoparticles Using Partially Water-Miscible Mixed Solvent Microdroplets as a Precursor

We present a versatile continuous microfluidic flow-focusing method for the production of Doxorubicin (DOX) or Tamoxifen (TAM)-loaded poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). We use a partially water-miscible solvent mixture (dimethyl sulfoxide DMSO+ dichloromethane DCM) as prec...

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Detalles Bibliográficos
Autores principales:	Xu, Jiang, Zhang, Shusheng, Machado, Anais, Lecommandoux, Sébastien, Sandre, Olivier, Gu, Frank, Colin, Annie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500499/ https://www.ncbi.nlm.nih.gov/pubmed/28684775 http://dx.doi.org/10.1038/s41598-017-05184-5

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