Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis

Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), the key protein in the chaperone-mediated autophagy (CMA) pathway, is elevated in breast tumor tissues. However, the exact effects and mechanisms of CMA during breast cancer metastasis remain largel...

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Detalles Bibliográficos
Autores principales: Han, Qi, Deng, Youcai, Chen, Sha, Chen, Rui, Yang, Mingzhen, Zhang, Zhujun, Sun, Xiongshan, Wang, Wei, He, Ying, Wang, Fangjie, Pan, Xiaodong, Li, Peng, Lai, Wenjing, Luo, Hongqin, Huang, Pei, Guan, Xiao, Deng, Yafei, Yan, Jun, Xu, Xianjie, Wen, Yan, Chen, An, Hu, Chuanmin, Li, Xiaohui, Li, Shuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500507/
https://www.ncbi.nlm.nih.gov/pubmed/28684853
http://dx.doi.org/10.1038/s41598-017-04994-x

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