Polysulfide Na(2)S(4) regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts

Electrophiles can activate redox signal transduction pathways, through actions of effector molecules (e.g., kinases and transcription factors) and sensor proteins with low pKa thiols that are covalently modified. In this study, we investigated whether 1,4-naphthoquinone (1,4-NQ) could affect the pho...

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Detalles Bibliográficos
Autores principales: Abiko, Yumi, Shinkai, Yasuhiro, Unoki, Takamitsu, Hirose, Reiko, Uehara, Takashi, Kumagai, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500523/
https://www.ncbi.nlm.nih.gov/pubmed/28684787
http://dx.doi.org/10.1038/s41598-017-04590-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500523/
https://www.ncbi.nlm.nih.gov/pubmed/28684787
http://dx.doi.org/10.1038/s41598-017-04590-z

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