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The normal environment delays the development of multisensory integration
Multisensory neurons in animals whose cross-modal experiences are compromised during early life fail to develop the ability to integrate information across those senses. Consequently, they lack the ability to increase the physiological salience of the events that provide the convergent cross-modal i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500544/ https://www.ncbi.nlm.nih.gov/pubmed/28684852 http://dx.doi.org/10.1038/s41598-017-05118-1 |
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author | Xu, Jinghong Yu, Liping Rowland, Benjamin A. Stein, Barry E. |
author_facet | Xu, Jinghong Yu, Liping Rowland, Benjamin A. Stein, Barry E. |
author_sort | Xu, Jinghong |
collection | PubMed |
description | Multisensory neurons in animals whose cross-modal experiences are compromised during early life fail to develop the ability to integrate information across those senses. Consequently, they lack the ability to increase the physiological salience of the events that provide the convergent cross-modal inputs. The present study demonstrates that superior colliculus (SC) neurons in animals whose visual-auditory experience is compromised early in life by noise-rearing can develop visual-auditory multisensory integration capabilities rapidly when periodically exposed to a single set of visual-auditory stimuli in a controlled laboratory paradigm. However, they remain compromised if their experiences are limited to a normal housing environment. These observations seem counterintuitive given that multisensory integrative capabilities ordinarily develop during early life in normal environments, in which a wide variety of sensory stimuli facilitate the functional organization of complex neural circuits at multiple levels of the neuraxis. However, the very richness and inherent variability of sensory stimuli in normal environments will lead to a less regular coupling of any given set of cross-modal cues than does the otherwise “impoverished” laboratory exposure paradigm. That this poses no significant problem for the neonate, but does for the adult, indicates a maturational shift in the requirements for the development of multisensory integration capabilities. |
format | Online Article Text |
id | pubmed-5500544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55005442017-07-10 The normal environment delays the development of multisensory integration Xu, Jinghong Yu, Liping Rowland, Benjamin A. Stein, Barry E. Sci Rep Article Multisensory neurons in animals whose cross-modal experiences are compromised during early life fail to develop the ability to integrate information across those senses. Consequently, they lack the ability to increase the physiological salience of the events that provide the convergent cross-modal inputs. The present study demonstrates that superior colliculus (SC) neurons in animals whose visual-auditory experience is compromised early in life by noise-rearing can develop visual-auditory multisensory integration capabilities rapidly when periodically exposed to a single set of visual-auditory stimuli in a controlled laboratory paradigm. However, they remain compromised if their experiences are limited to a normal housing environment. These observations seem counterintuitive given that multisensory integrative capabilities ordinarily develop during early life in normal environments, in which a wide variety of sensory stimuli facilitate the functional organization of complex neural circuits at multiple levels of the neuraxis. However, the very richness and inherent variability of sensory stimuli in normal environments will lead to a less regular coupling of any given set of cross-modal cues than does the otherwise “impoverished” laboratory exposure paradigm. That this poses no significant problem for the neonate, but does for the adult, indicates a maturational shift in the requirements for the development of multisensory integration capabilities. Nature Publishing Group UK 2017-07-06 /pmc/articles/PMC5500544/ /pubmed/28684852 http://dx.doi.org/10.1038/s41598-017-05118-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xu, Jinghong Yu, Liping Rowland, Benjamin A. Stein, Barry E. The normal environment delays the development of multisensory integration |
title | The normal environment delays the development of multisensory integration |
title_full | The normal environment delays the development of multisensory integration |
title_fullStr | The normal environment delays the development of multisensory integration |
title_full_unstemmed | The normal environment delays the development of multisensory integration |
title_short | The normal environment delays the development of multisensory integration |
title_sort | normal environment delays the development of multisensory integration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500544/ https://www.ncbi.nlm.nih.gov/pubmed/28684852 http://dx.doi.org/10.1038/s41598-017-05118-1 |
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