Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs

Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-phi...

Descripción completa

Detalles Bibliográficos
Autores principales: Papathanasiou, Konstantinos E., Turhanen, Petri, Brückner, Stephan I., Brunner, Eike, Demadis, Konstantinos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500573/
https://www.ncbi.nlm.nih.gov/pubmed/28684783
http://dx.doi.org/10.1038/s41598-017-04956-3
Descripción
Sumario:Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.

Ejemplares similares