Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs

Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-phi...

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Autores principales: Papathanasiou, Konstantinos E., Turhanen, Petri, Brückner, Stephan I., Brunner, Eike, Demadis, Konstantinos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500573/
https://www.ncbi.nlm.nih.gov/pubmed/28684783
http://dx.doi.org/10.1038/s41598-017-04956-3
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author Papathanasiou, Konstantinos E.
Turhanen, Petri
Brückner, Stephan I.
Brunner, Eike
Demadis, Konstantinos D.
author_facet Papathanasiou, Konstantinos E.
Turhanen, Petri
Brückner, Stephan I.
Brunner, Eike
Demadis, Konstantinos D.
author_sort Papathanasiou, Konstantinos E.
collection PubMed
description Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.
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spelling pubmed-55005732017-07-10 Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs Papathanasiou, Konstantinos E. Turhanen, Petri Brückner, Stephan I. Brunner, Eike Demadis, Konstantinos D. Sci Rep Article Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable. Nature Publishing Group UK 2017-07-06 /pmc/articles/PMC5500573/ /pubmed/28684783 http://dx.doi.org/10.1038/s41598-017-04956-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Papathanasiou, Konstantinos E.
Turhanen, Petri
Brückner, Stephan I.
Brunner, Eike
Demadis, Konstantinos D.
Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
title Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
title_full Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
title_fullStr Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
title_full_unstemmed Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
title_short Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
title_sort smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500573/
https://www.ncbi.nlm.nih.gov/pubmed/28684783
http://dx.doi.org/10.1038/s41598-017-04956-3
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