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Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demon...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500581/ https://www.ncbi.nlm.nih.gov/pubmed/28684756 http://dx.doi.org/10.1038/s41598-017-04659-9 |
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author | Cormode, David P. Si-Mohamed, Salim Bar-Ness, Daniel Sigovan, Monica Naha, Pratap C. Balegamire, Joelle Lavenne, Franck Coulon, Philippe Roessl, Ewald Bartels, Matthias Rokni, Michal Blevis, Ira Boussel, Loic Douek, Philippe |
author_facet | Cormode, David P. Si-Mohamed, Salim Bar-Ness, Daniel Sigovan, Monica Naha, Pratap C. Balegamire, Joelle Lavenne, Franck Coulon, Philippe Roessl, Ewald Bartels, Matthias Rokni, Michal Blevis, Ira Boussel, Loic Douek, Philippe |
author_sort | Cormode, David P. |
collection | PubMed |
description | A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents’ concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo. |
format | Online Article Text |
id | pubmed-5500581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55005812017-07-10 Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner Cormode, David P. Si-Mohamed, Salim Bar-Ness, Daniel Sigovan, Monica Naha, Pratap C. Balegamire, Joelle Lavenne, Franck Coulon, Philippe Roessl, Ewald Bartels, Matthias Rokni, Michal Blevis, Ira Boussel, Loic Douek, Philippe Sci Rep Article A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents’ concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo. Nature Publishing Group UK 2017-07-06 /pmc/articles/PMC5500581/ /pubmed/28684756 http://dx.doi.org/10.1038/s41598-017-04659-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cormode, David P. Si-Mohamed, Salim Bar-Ness, Daniel Sigovan, Monica Naha, Pratap C. Balegamire, Joelle Lavenne, Franck Coulon, Philippe Roessl, Ewald Bartels, Matthias Rokni, Michal Blevis, Ira Boussel, Loic Douek, Philippe Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
title | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
title_full | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
title_fullStr | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
title_full_unstemmed | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
title_short | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
title_sort | multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500581/ https://www.ncbi.nlm.nih.gov/pubmed/28684756 http://dx.doi.org/10.1038/s41598-017-04659-9 |
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