Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model

Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH intracellular domain. However, the clinical outcome of GSI remains unsatisfactor...

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Detalles Bibliográficos
Autores principales: Hubmann, Rainer, Sieghart, Wolfgang, Schnabl, Susanne, Araghi, Mohammad, Hilgarth, Martin, Reiter, Marlies, Demirtas, Dita, Valent, Peter, Zielinski, Christoph, Jäger, Ulrich, Shehata, Medhat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500618/
https://www.ncbi.nlm.nih.gov/pubmed/28736522
http://dx.doi.org/10.3389/fphar.2017.00319

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