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New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network

Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of cancer. Besides, microRNAs (miRNAs) act vital rol...

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Detalles Bibliográficos
Autores principales: Zhou, Kecheng, Liu, Minxia, Cao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500619/
https://www.ncbi.nlm.nih.gov/pubmed/28736730
http://dx.doi.org/10.3389/fmolb.2017.00046
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author Zhou, Kecheng
Liu, Minxia
Cao, Yi
author_facet Zhou, Kecheng
Liu, Minxia
Cao, Yi
author_sort Zhou, Kecheng
collection PubMed
description Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of cancer. Besides, microRNAs (miRNAs) act vital roles in tumorigenesis through regulating some oncogenes and TSGs. Interestingly, miRNAs are also regulated by oncogenes and TSGs. Considering the entangled regulation, here we propose a new insight into these regulation relationships in cancer: oncogene–miRNA–TSG network, which further emphasizes roles of miRNA, as well as highlights the network regulation among oncogene, miRNA, and TSG during tumorigenesis. The oncogene–miRNA–TSG network demonstrates that oncogenes and TSGs not only show functional synergy, but also there are regulatory relationships among oncogenes and TSGs during tumorigenesis, which could be mediated by miRNAs. In view of the oncogene–miRNA–TSG network involved in many oncogenes, miRNAs, and TSGs, as well as occurring in various tumor types, the anomaly of this network may be a common event in cancers and participates in tumorigenesis. This hypothesis broadens horizons of molecular mechanisms underlying tumorigenesis, and may provide a new promising venue for the prediction, diagnosis, and even therapy of cancer.
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spelling pubmed-55006192017-07-21 New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network Zhou, Kecheng Liu, Minxia Cao, Yi Front Mol Biosci Molecular Biosciences Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of cancer. Besides, microRNAs (miRNAs) act vital roles in tumorigenesis through regulating some oncogenes and TSGs. Interestingly, miRNAs are also regulated by oncogenes and TSGs. Considering the entangled regulation, here we propose a new insight into these regulation relationships in cancer: oncogene–miRNA–TSG network, which further emphasizes roles of miRNA, as well as highlights the network regulation among oncogene, miRNA, and TSG during tumorigenesis. The oncogene–miRNA–TSG network demonstrates that oncogenes and TSGs not only show functional synergy, but also there are regulatory relationships among oncogenes and TSGs during tumorigenesis, which could be mediated by miRNAs. In view of the oncogene–miRNA–TSG network involved in many oncogenes, miRNAs, and TSGs, as well as occurring in various tumor types, the anomaly of this network may be a common event in cancers and participates in tumorigenesis. This hypothesis broadens horizons of molecular mechanisms underlying tumorigenesis, and may provide a new promising venue for the prediction, diagnosis, and even therapy of cancer. Frontiers Media S.A. 2017-07-07 /pmc/articles/PMC5500619/ /pubmed/28736730 http://dx.doi.org/10.3389/fmolb.2017.00046 Text en Copyright © 2017 Zhou, Liu and Cao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Zhou, Kecheng
Liu, Minxia
Cao, Yi
New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network
title New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network
title_full New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network
title_fullStr New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network
title_full_unstemmed New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network
title_short New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network
title_sort new insight into microrna functions in cancer: oncogene–microrna–tumor suppressor gene network
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500619/
https://www.ncbi.nlm.nih.gov/pubmed/28736730
http://dx.doi.org/10.3389/fmolb.2017.00046
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