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Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis via Targeting Pathogenic Antigen-Specific Th17-Type Cells

The Ras family of GTPases plays an important role in signaling nodes downstream to T cell receptor and CD28 activation, potentially lowering the threshold for T-cell receptor activation by autoantigens. Somatic mutation in NRAS or KRAS may cause a rare autoimmune disorder coupled with abnormal expan...

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Detalles Bibliográficos
Autores principales:	Zayoud, Morad, Marcu-Malina, Victoria, Vax, Einav, Jacob-Hirsch, Jasmine, Elad-Sfadia, Galit, Barshack, Iris, Kloog, Yoel, Goldstein, Itamar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500629/ https://www.ncbi.nlm.nih.gov/pubmed/28736556 http://dx.doi.org/10.3389/fimmu.2017.00799

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