A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK

Cdc42 is a Rho-family small G protein that has been widely studied for its role in controlling the actin cytoskeleton and plays a part in several potentially oncogenic signaling networks. Similar to most other small G proteins, Cdc42 binds to many downstream effector proteins to elicit its cellular...

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Detalles Bibliográficos
Autores principales: Tetley, George J. N., Mott, Helen R., Cooley, R. Neil, Owen, Darerca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500802/
https://www.ncbi.nlm.nih.gov/pubmed/28539360
http://dx.doi.org/10.1074/jbc.M117.789883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500802/
https://www.ncbi.nlm.nih.gov/pubmed/28539360
http://dx.doi.org/10.1074/jbc.M117.789883

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