Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) me...

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Detalles Bibliográficos
Autores principales: Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Del Rey, Maria Quiles, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500878/
https://www.ncbi.nlm.nih.gov/pubmed/28671190
http://dx.doi.org/10.1038/ncomms15965

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