The m(6)A pathway facilitates sex determination in Drosophila

The conserved modification N(6)-methyladenosine (m(6)A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m(6)A pathway. We first apply miCLIP to map m(6)A across embryogenesis, characterize its m(6)A ‘writer’ complex, validate its YTH ‘readers’ CG6422 and...

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Detalles Bibliográficos
Autores principales: Kan, Lijuan, Grozhik, Anya V., Vedanayagam, Jeffrey, Patil, Deepak P., Pang, Nan, Lim, Kok-Seong, Huang, Yi-Chun, Joseph, Brian, Lin, Ching-Jung, Despic, Vladimir, Guo, Jian, Yan, Dong, Kondo, Shu, Deng, Wu-Min, Dedon, Peter C., Jaffrey, Samie R., Lai, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500889/
https://www.ncbi.nlm.nih.gov/pubmed/28675155
http://dx.doi.org/10.1038/ncomms15737

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