The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases. In particular, the protein kinases are responsible for cellular transduction signaling...

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Autores principales: Ardito, Fatima, Giuliani, Michele, Perrone, Donatella, Troiano, Giuseppe, Muzio, Lorenzo Lo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500920/
https://www.ncbi.nlm.nih.gov/pubmed/28656226
http://dx.doi.org/10.3892/ijmm.2017.3036
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author Ardito, Fatima
Giuliani, Michele
Perrone, Donatella
Troiano, Giuseppe
Muzio, Lorenzo Lo
author_facet Ardito, Fatima
Giuliani, Michele
Perrone, Donatella
Troiano, Giuseppe
Muzio, Lorenzo Lo
author_sort Ardito, Fatima
collection PubMed
description Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors.
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spelling pubmed-55009202017-07-12 The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) Ardito, Fatima Giuliani, Michele Perrone, Donatella Troiano, Giuseppe Muzio, Lorenzo Lo Int J Mol Med Articles Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors. D.A. Spandidos 2017-08 2017-06-22 /pmc/articles/PMC5500920/ /pubmed/28656226 http://dx.doi.org/10.3892/ijmm.2017.3036 Text en Copyright: © Ardito et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Ardito, Fatima
Giuliani, Michele
Perrone, Donatella
Troiano, Giuseppe
Muzio, Lorenzo Lo
The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
title The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
title_full The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
title_fullStr The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
title_full_unstemmed The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
title_short The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
title_sort crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500920/
https://www.ncbi.nlm.nih.gov/pubmed/28656226
http://dx.doi.org/10.3892/ijmm.2017.3036
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