Pentapeptides for the treatment of small cell lung cancer: Optimisation by N(ind)-alkyl modification of the tryptophan side chain

The pentapeptide, tert-Prenyl(4th)-NH(2) (DMePhe-DTrp-Phe-DTrp(N-tert-prenyl)-Leu-NH(2)), has recently been reported by our group to exhibit properties of substance P (SP) antagonist G against small cell lung cancer (SCLC). In this study, we undertook a systematic structure activity investigation to...

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Detalles Bibliográficos
Autores principales: Haitham Abusara, Osama, Freeman, Sally, Aojula, Harmesh Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500990/
https://www.ncbi.nlm.nih.gov/pubmed/28595067
http://dx.doi.org/10.1016/j.ejmech.2017.05.053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500990/
https://www.ncbi.nlm.nih.gov/pubmed/28595067
http://dx.doi.org/10.1016/j.ejmech.2017.05.053

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