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Pentapeptides for the treatment of small cell lung cancer: Optimisation by N(ind)-alkyl modification of the tryptophan side chain
The pentapeptide, tert-Prenyl(4th)-NH(2) (DMePhe-DTrp-Phe-DTrp(N-tert-prenyl)-Leu-NH(2)), has recently been reported by our group to exhibit properties of substance P (SP) antagonist G against small cell lung cancer (SCLC). In this study, we undertook a systematic structure activity investigation to...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Editions Scientifiques Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500990/ https://www.ncbi.nlm.nih.gov/pubmed/28595067 http://dx.doi.org/10.1016/j.ejmech.2017.05.053 |