Cargando…
Substituted arylsulphonamides as inhibitors of perforin-mediated lysis
The structure-activity relationships for a series of arylsulphonamide-based inhibitors of the pore-forming protein perforin have been explored. Perforin is a key component of the human immune response, however inappropriate activity has also been implicated in certain auto-immune and therapy-induced...
Autores principales: | Spicer, Julie A., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Huttunen, Kristiina M., Jaiswal, Jagdish K., Denny, William A., Akhlaghi, Hedieh, Browne, Kylie A., Trapani, Joseph A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editions Scientifiques Elsevier
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500991/ https://www.ncbi.nlm.nih.gov/pubmed/28582670 http://dx.doi.org/10.1016/j.ejmech.2017.05.048 |
Ejemplares similares
-
Benzenesulphonamide inhibitors of the cytolytic protein perforin
por: Spicer, Julie A., et al.
Publicado: (2017) -
Diarylthiophenes as inhibitors of the pore-forming protein perforin
por: Miller, Christian K., et al.
Publicado: (2016) -
Small Molecule
Inhibitors of Lymphocyte Perforin as
Focused Immunosuppressants for Infection and Autoimmunity
por: Spicer, Julie A., et al.
Publicado: (2022) -
Preclinical Activity and Pharmacokinetic/Pharmacodynamic
Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors
por: Gartlan, Kate H., et al.
Publicado: (2022) -
Exploration of a Series of
5-Arylidene-2-thioxoimidazolidin-4-ones
as Inhibitors of the Cytolytic Protein Perforin
por: Spicer, Julie A., et al.
Publicado: (2013)