Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer

Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on findings from early studies that were biased toward young and transpositionally active elements. Here, we investigate the relationship between methylati...

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Detalles Bibliográficos
Autores principales: Vafadar-Isfahani, Natasha, Parr, Christina, McMillan, Lara E., Sanner, Juliane, Yeo, Zhao, Saddington, Stephen, Peacock, Oliver, Cruickshanks, Hazel A., Meehan, Richard R., Lund, Jonathan N., Tufarelli, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501206/
https://www.ncbi.nlm.nih.gov/pubmed/28300471
http://dx.doi.org/10.1080/15592294.2017.1300729

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