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Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery
BACKGROUND: Biomarkers derived from neural activity of the brain present a vital tool for the prediction and evaluation of post-stroke motor recovery, as well as for real-time biofeedback opportunities. METHODS: In order to encapsulate recovery-related reorganization of brain networks into such biom...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501348/ https://www.ncbi.nlm.nih.gov/pubmed/28683745 http://dx.doi.org/10.1186/s12984-017-0277-3 |
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author | Philips, Gavin R. Daly, Janis J. Príncipe, José C. |
author_facet | Philips, Gavin R. Daly, Janis J. Príncipe, José C. |
author_sort | Philips, Gavin R. |
collection | PubMed |
description | BACKGROUND: Biomarkers derived from neural activity of the brain present a vital tool for the prediction and evaluation of post-stroke motor recovery, as well as for real-time biofeedback opportunities. METHODS: In order to encapsulate recovery-related reorganization of brain networks into such biomarkers, we have utilized the generalized measure of association (GMA) and graph analyses, which include global and local efficiency, as well as hemispheric interdensity and intradensity. These methods were applied to electroencephalogram (EEG) data recorded during a study of 30 stroke survivors (21 male, mean age 57.9 years, mean stroke duration 22.4 months) undergoing 12 weeks of intensive therapeutic intervention. RESULTS: We observed that decreases of the intradensity of the unaffected hemisphere are correlated (r (s)=−0.46;p<0.05) with functional recovery, as measured by the upper-extremity portion of the Fugl-Meyer Assessment (FMUE). In addition, high initial values of local efficiency predict greater improvement in FMUE (R (2)=0.16;p<0.05). In a subset of 17 subjects possessing lesions of the cerebral cortex, reductions of global and local efficiency, as well as the intradensity of the unaffected hemisphere are found to be associated with functional improvement (r (s)=−0.60,−0.66,−0.75;p<0.05). Within the same subgroup, high initial values of global and local efficiency, are predictive of improved recovery (R (2)=0.24,0.25;p<0.05). All significant findings were specific to the 12.5–25 Hz band. CONCLUSIONS: These topological measures show promise for prognosis and evaluation of therapeutic outcomes, as well as potential application to BCI-enabled biofeedback. |
format | Online Article Text |
id | pubmed-5501348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55013482017-07-10 Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery Philips, Gavin R. Daly, Janis J. Príncipe, José C. J Neuroeng Rehabil Research BACKGROUND: Biomarkers derived from neural activity of the brain present a vital tool for the prediction and evaluation of post-stroke motor recovery, as well as for real-time biofeedback opportunities. METHODS: In order to encapsulate recovery-related reorganization of brain networks into such biomarkers, we have utilized the generalized measure of association (GMA) and graph analyses, which include global and local efficiency, as well as hemispheric interdensity and intradensity. These methods were applied to electroencephalogram (EEG) data recorded during a study of 30 stroke survivors (21 male, mean age 57.9 years, mean stroke duration 22.4 months) undergoing 12 weeks of intensive therapeutic intervention. RESULTS: We observed that decreases of the intradensity of the unaffected hemisphere are correlated (r (s)=−0.46;p<0.05) with functional recovery, as measured by the upper-extremity portion of the Fugl-Meyer Assessment (FMUE). In addition, high initial values of local efficiency predict greater improvement in FMUE (R (2)=0.16;p<0.05). In a subset of 17 subjects possessing lesions of the cerebral cortex, reductions of global and local efficiency, as well as the intradensity of the unaffected hemisphere are found to be associated with functional improvement (r (s)=−0.60,−0.66,−0.75;p<0.05). Within the same subgroup, high initial values of global and local efficiency, are predictive of improved recovery (R (2)=0.24,0.25;p<0.05). All significant findings were specific to the 12.5–25 Hz band. CONCLUSIONS: These topological measures show promise for prognosis and evaluation of therapeutic outcomes, as well as potential application to BCI-enabled biofeedback. BioMed Central 2017-07-06 /pmc/articles/PMC5501348/ /pubmed/28683745 http://dx.doi.org/10.1186/s12984-017-0277-3 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Philips, Gavin R. Daly, Janis J. Príncipe, José C. Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery |
title | Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery |
title_full | Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery |
title_fullStr | Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery |
title_full_unstemmed | Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery |
title_short | Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery |
title_sort | topographical measures of functional connectivity as biomarkers for post-stroke motor recovery |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501348/ https://www.ncbi.nlm.nih.gov/pubmed/28683745 http://dx.doi.org/10.1186/s12984-017-0277-3 |
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