Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code

BACKGROUND: Middle-down mass spectrometry (MS), i.e., analysis of long (~50–60 aa) polypeptides, has become the method with the highest throughput and accuracy for the characterization of combinatorial histone posttranslational modifications (PTMs). The discovery of histone readers with multiple dom...

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Detalles Bibliográficos
Autores principales: Sidoli, Simone, Lu, Congcong, Coradin, Mariel, Wang, Xiaoshi, Karch, Kelly R., Ruminowicz, Chrystian, Garcia, Benjamin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501349/
https://www.ncbi.nlm.nih.gov/pubmed/28683815
http://dx.doi.org/10.1186/s13072-017-0139-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501349/
https://www.ncbi.nlm.nih.gov/pubmed/28683815
http://dx.doi.org/10.1186/s13072-017-0139-z

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