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Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code
BACKGROUND: Middle-down mass spectrometry (MS), i.e., analysis of long (~50–60 aa) polypeptides, has become the method with the highest throughput and accuracy for the characterization of combinatorial histone posttranslational modifications (PTMs). The discovery of histone readers with multiple dom...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501349/ https://www.ncbi.nlm.nih.gov/pubmed/28683815 http://dx.doi.org/10.1186/s13072-017-0139-z |