Same same but different: The evolution of TBP in archaea and their eukaryotic offspring

Transcription factors TBP and TF(II)B assemble with RNA polymerase at the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we specula...

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Detalles Bibliográficos
Autores principales: Blombach, Fabian, Grohmann, Dina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501381/
https://www.ncbi.nlm.nih.gov/pubmed/28340330
http://dx.doi.org/10.1080/21541264.2017.1289879
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author Blombach, Fabian
Grohmann, Dina
author_facet Blombach, Fabian
Grohmann, Dina
author_sort Blombach, Fabian
collection PubMed
description Transcription factors TBP and TF(II)B assemble with RNA polymerase at the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity.
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spelling pubmed-55013812017-07-12 Same same but different: The evolution of TBP in archaea and their eukaryotic offspring Blombach, Fabian Grohmann, Dina Transcription Point-of-View Transcription factors TBP and TF(II)B assemble with RNA polymerase at the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity. Taylor & Francis 2017-02-08 /pmc/articles/PMC5501381/ /pubmed/28340330 http://dx.doi.org/10.1080/21541264.2017.1289879 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point-of-View
Blombach, Fabian
Grohmann, Dina
Same same but different: The evolution of TBP in archaea and their eukaryotic offspring
title Same same but different: The evolution of TBP in archaea and their eukaryotic offspring
title_full Same same but different: The evolution of TBP in archaea and their eukaryotic offspring
title_fullStr Same same but different: The evolution of TBP in archaea and their eukaryotic offspring
title_full_unstemmed Same same but different: The evolution of TBP in archaea and their eukaryotic offspring
title_short Same same but different: The evolution of TBP in archaea and their eukaryotic offspring
title_sort same same but different: the evolution of tbp in archaea and their eukaryotic offspring
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501381/
https://www.ncbi.nlm.nih.gov/pubmed/28340330
http://dx.doi.org/10.1080/21541264.2017.1289879
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