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Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations
We present an integrated experimental and computational approach for de novo protein structure determination in which short-distance cross-linking data are incorporated into rapid discrete molecular dynamics (DMD) simulations as constraints, reducing the conformational space and achieving the correc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501500/ https://www.ncbi.nlm.nih.gov/pubmed/28695211 http://dx.doi.org/10.1126/sciadv.1700479 |