TRPA1 channels promote astrocytic Ca(2+) hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

BACKGROUND: Excessive synaptic loss is thought to be one of the earliest events in Alzheimer’s disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes contribute to fu...

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Detalles Bibliográficos
Autores principales: Bosson, Anthony, Paumier, Adrien, Boisseau, Sylvie, Jacquier-Sarlin, Muriel, Buisson, Alain, Albrieux, Mireille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501536/
https://www.ncbi.nlm.nih.gov/pubmed/28683776
http://dx.doi.org/10.1186/s13024-017-0194-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501536/
https://www.ncbi.nlm.nih.gov/pubmed/28683776
http://dx.doi.org/10.1186/s13024-017-0194-8

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