Transmembrane helical interactions in the CFTR channel pore

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulation of epithelial fluid transport in the lung, pancreas and other organs in cystic fibrosis (CF). Development of pharmaceutica...

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Detalles Bibliográficos
Autores principales: Das, Jhuma, Aleksandrov, Andrei A., Cui, Liying, He, Lihua, Riordan, John R., Dokholyan, Nikolay V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501672/
https://www.ncbi.nlm.nih.gov/pubmed/28640808
http://dx.doi.org/10.1371/journal.pcbi.1005594

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