Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia

Heliosterpenoids A and B (1 and 2), two unprecedented jatrophane-derived diterpenoid esters with a novel 5/6/4/6-fused tetracyclic ring skeleton, were isolated from the whole plants of Euphorbia helioscopia. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and electronic...

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Autores principales: Mai, Zhen-Peng, Ni, Gang, Liu, Yan-Fei, Li, Li, Shi, Guo-Ru, Wang, Xin, Li, Jia-Yuan, Yu, De-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501787/
https://www.ncbi.nlm.nih.gov/pubmed/28687752
http://dx.doi.org/10.1038/s41598-017-04399-w
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author Mai, Zhen-Peng
Ni, Gang
Liu, Yan-Fei
Li, Li
Shi, Guo-Ru
Wang, Xin
Li, Jia-Yuan
Yu, De-Quan
author_facet Mai, Zhen-Peng
Ni, Gang
Liu, Yan-Fei
Li, Li
Shi, Guo-Ru
Wang, Xin
Li, Jia-Yuan
Yu, De-Quan
author_sort Mai, Zhen-Peng
collection PubMed
description Heliosterpenoids A and B (1 and 2), two unprecedented jatrophane-derived diterpenoid esters with a novel 5/6/4/6-fused tetracyclic ring skeleton, were isolated from the whole plants of Euphorbia helioscopia. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. The plausible biogenetic pathways of 1 and 2 were postulated. 1 and 2 were found to be potent inhibitors of P-glycoprotein (ABCB1) and 1 also exhibited cytotoxicity against MDA-MB-231 cell lines.
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spelling pubmed-55017872017-07-10 Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia Mai, Zhen-Peng Ni, Gang Liu, Yan-Fei Li, Li Shi, Guo-Ru Wang, Xin Li, Jia-Yuan Yu, De-Quan Sci Rep Article Heliosterpenoids A and B (1 and 2), two unprecedented jatrophane-derived diterpenoid esters with a novel 5/6/4/6-fused tetracyclic ring skeleton, were isolated from the whole plants of Euphorbia helioscopia. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. The plausible biogenetic pathways of 1 and 2 were postulated. 1 and 2 were found to be potent inhibitors of P-glycoprotein (ABCB1) and 1 also exhibited cytotoxicity against MDA-MB-231 cell lines. Nature Publishing Group UK 2017-07-07 /pmc/articles/PMC5501787/ /pubmed/28687752 http://dx.doi.org/10.1038/s41598-017-04399-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mai, Zhen-Peng
Ni, Gang
Liu, Yan-Fei
Li, Li
Shi, Guo-Ru
Wang, Xin
Li, Jia-Yuan
Yu, De-Quan
Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_full Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_fullStr Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_full_unstemmed Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_short Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_sort heliosterpenoids a and b, two novel jatrophane-derived diterpenoids with a 5/6/4/6 ring system from euphorbia helioscopia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501787/
https://www.ncbi.nlm.nih.gov/pubmed/28687752
http://dx.doi.org/10.1038/s41598-017-04399-w
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