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Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping
T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverag...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501789/ https://www.ncbi.nlm.nih.gov/pubmed/28687810 http://dx.doi.org/10.1038/s41598-017-05127-0 |
Sumario: | T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverage for the AAR by T1 and T2 mapping and MI size. Forty-eight STEMI patients were prospectively recruited and underwent a CMR at 4 ± 2 days. There was no difference between the AAR(full LV) and AAR(3-slices) by T1 (P = 0.054) and T2-mapping (P = 0.092), with good correlations but small biases and wide limits of agreements (T1-mapping: N = 30, R(2) = 0.85, bias = 1.7 ± 9.4% LV; T2-mapping: N = 48, R(2) = 0.75, bias = 1.7 ± 12.9% LV). There was also no significant difference between MI size(3-slices) and MI size(full LV) (P = 0.93) with an excellent correlation between the two (R(2) 0.92) but a small bias of 0.5% and a wide limit of agreement of ±7.7%. Although MSI was similar between the 2 approaches, MSI(3-slices) performed poorly when MSI was <0.50. Furthermore, using AAR(3-slices) and MI size(full LV) resulted in ‘negative’ MSI in 7/48 patients. Full LV coverage T1 and T2 mapping are more accurate than a 3-slice approach for delineating the AAR, especially in those with MSI < 0.50 and we would advocate full LV coverage in future studies. |
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