Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease, including systemic inflammation and cartilage...

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Detalles Bibliográficos
Autores principales: Wang, Chun, Xu, Can-Xin, Alippe, Yael, Qu, Chao, Xiao, Jianqiu, Schipani, Ernestina, Civitelli, Roberto, Abu-Amer, Yousef, Mbalaviele, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501802/
https://www.ncbi.nlm.nih.gov/pubmed/28687790
http://dx.doi.org/10.1038/s41598-017-05033-5

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