Successful haploidentical stem cell transplantation with prophylactic administration of liposomal amphotericin B after invasive pulmonary zygomycosis

A 54-year-old woman with acute myeloid leukemia (AML) achieved complete remission by induction chemotherapy, but developed zygomycosis after consolidation therapy. As zygomycosis could not be cured by liposomal amphotericin B and micafungin, left lower lobectomy was performed. As AML relapsed 7 mont...

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Detalles Bibliográficos
Autores principales: Ochi, Testuro, Katayama, Yuta, Okatani, Takeshi, Imanaka, Ryota, Kyo, Kohei, Itagaki, Mitsuhiro, Katsutani, Shinya, Iwato, Koji, Asaoku, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501889/
https://www.ncbi.nlm.nih.gov/pubmed/28725544
http://dx.doi.org/10.1016/j.mmcr.2017.07.002
Descripción
Sumario:A 54-year-old woman with acute myeloid leukemia (AML) achieved complete remission by induction chemotherapy, but developed zygomycosis after consolidation therapy. As zygomycosis could not be cured by liposomal amphotericin B and micafungin, left lower lobectomy was performed. As AML relapsed 7 months after onset, she received haploidentical stem cell transplantation under administration of liposomal amphotericin B. Despite experiencing severe acute graft-versus-host disease, she remains alive with no relapse of either zygomycosis or AML.

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