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Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial
BACKGROUND: This study aimed to assess the efficacy and safety of atropine 0.5% eyedrops (ATE) for the treatment of children with low myopia (LM). METHODS: In this study, a total of 126 children with LM were randomly divided into an intervention group (administered 0.5% ATE) and a control group (adm...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502160/ https://www.ncbi.nlm.nih.gov/pubmed/28682887 http://dx.doi.org/10.1097/MD.0000000000007371 |
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author | Wang, Yan-rong Bian, Hong-Li Wang, Qi |
author_facet | Wang, Yan-rong Bian, Hong-Li Wang, Qi |
author_sort | Wang, Yan-rong |
collection | PubMed |
description | BACKGROUND: This study aimed to assess the efficacy and safety of atropine 0.5% eyedrops (ATE) for the treatment of children with low myopia (LM). METHODS: In this study, a total of 126 children with LM were randomly divided into an intervention group (administered 0.5% ATE) and a control group (administered a placebo), with 63 children in each group. The outcome measurements were changes in the spherical equivalent (SE), and axial length (AL), as well as adverse events (AEs). RESULTS: Compared with placebo, administration of 0.5% ATE led to less progression in LM, as measured by SE, and less increase in AL (P < .01). In addition, no serious AEs occurred in both the groups. CONCLUSION: About 0.5% ATE was efficacious and safe for controlling myopia in children with LM. |
format | Online Article Text |
id | pubmed-5502160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-55021602017-07-18 Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial Wang, Yan-rong Bian, Hong-Li Wang, Qi Medicine (Baltimore) 3800 BACKGROUND: This study aimed to assess the efficacy and safety of atropine 0.5% eyedrops (ATE) for the treatment of children with low myopia (LM). METHODS: In this study, a total of 126 children with LM were randomly divided into an intervention group (administered 0.5% ATE) and a control group (administered a placebo), with 63 children in each group. The outcome measurements were changes in the spherical equivalent (SE), and axial length (AL), as well as adverse events (AEs). RESULTS: Compared with placebo, administration of 0.5% ATE led to less progression in LM, as measured by SE, and less increase in AL (P < .01). In addition, no serious AEs occurred in both the groups. CONCLUSION: About 0.5% ATE was efficacious and safe for controlling myopia in children with LM. Wolters Kluwer Health 2017-07-07 /pmc/articles/PMC5502160/ /pubmed/28682887 http://dx.doi.org/10.1097/MD.0000000000007371 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 3800 Wang, Yan-rong Bian, Hong-Li Wang, Qi Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial |
title | Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial |
title_full | Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial |
title_fullStr | Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial |
title_full_unstemmed | Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial |
title_short | Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial |
title_sort | atropine 0.5% eyedrops for the treatment of children with low myopia: a randomized controlled trial |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502160/ https://www.ncbi.nlm.nih.gov/pubmed/28682887 http://dx.doi.org/10.1097/MD.0000000000007371 |
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