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Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications

Hydrogen sulfide (H(2)S) is a newly recognized gasotransmitter. Studies have demonstrated that the production of endogenous H(2)S and the exogenous administration of H(2)S can regulate many physiological and/or pathological processes. Therefore, H(2)S releasing agents (also known as H(2)S donors) ar...

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Autores principales: Kang, Jianming, Neill, Deshka L., Xian, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502280/
https://www.ncbi.nlm.nih.gov/pubmed/28740467
http://dx.doi.org/10.3389/fphar.2017.00457
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author Kang, Jianming
Neill, Deshka L.
Xian, Ming
author_facet Kang, Jianming
Neill, Deshka L.
Xian, Ming
author_sort Kang, Jianming
collection PubMed
description Hydrogen sulfide (H(2)S) is a newly recognized gasotransmitter. Studies have demonstrated that the production of endogenous H(2)S and the exogenous administration of H(2)S can regulate many physiological and/or pathological processes. Therefore, H(2)S releasing agents (also known as H(2)S donors) are important research tools in advancing our understanding of the biology and clinical potential of H(2)S. Among currently available donors, GYY4137 is probably the most well-known and has been used in many studies in the past 10 years. Recently, a number of GYY4137 derivatives (e.g., phosphonothioate-based compounds) have been developed as H(2)S donors. In this review, we summarize the development and application of these donors, which include Lawesson’s reagent, substituted phosphorodithioates, cyclic phosphorane analogs, and pH-controlled phosphonamidothioates (JK donors). These donors have advantages such as good water-solubility, slow and controllable H(2)S release capability, and a variety of reported biological activities. However, it should be noted that the detailed H(2)S release profiles and byproducts under real biological systems are still unclear for many of these donors. Only after we figure out these unknowns we will see better applications of these donors in H(2)S research and therapy.
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spelling pubmed-55022802017-07-24 Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications Kang, Jianming Neill, Deshka L. Xian, Ming Front Pharmacol Pharmacology Hydrogen sulfide (H(2)S) is a newly recognized gasotransmitter. Studies have demonstrated that the production of endogenous H(2)S and the exogenous administration of H(2)S can regulate many physiological and/or pathological processes. Therefore, H(2)S releasing agents (also known as H(2)S donors) are important research tools in advancing our understanding of the biology and clinical potential of H(2)S. Among currently available donors, GYY4137 is probably the most well-known and has been used in many studies in the past 10 years. Recently, a number of GYY4137 derivatives (e.g., phosphonothioate-based compounds) have been developed as H(2)S donors. In this review, we summarize the development and application of these donors, which include Lawesson’s reagent, substituted phosphorodithioates, cyclic phosphorane analogs, and pH-controlled phosphonamidothioates (JK donors). These donors have advantages such as good water-solubility, slow and controllable H(2)S release capability, and a variety of reported biological activities. However, it should be noted that the detailed H(2)S release profiles and byproducts under real biological systems are still unclear for many of these donors. Only after we figure out these unknowns we will see better applications of these donors in H(2)S research and therapy. Frontiers Media S.A. 2017-07-10 /pmc/articles/PMC5502280/ /pubmed/28740467 http://dx.doi.org/10.3389/fphar.2017.00457 Text en Copyright © 2017 Kang, Neill and Xian. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kang, Jianming
Neill, Deshka L.
Xian, Ming
Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications
title Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications
title_full Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications
title_fullStr Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications
title_full_unstemmed Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications
title_short Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications
title_sort phosphonothioate-based hydrogen sulfide releasing reagents: chemistry and biological applications
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502280/
https://www.ncbi.nlm.nih.gov/pubmed/28740467
http://dx.doi.org/10.3389/fphar.2017.00457
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