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Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity

Poly(ADP-ribose) polymerases (PARPs) are ADP-ribosylating enzymes and play important roles in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against PARP1, a poly-ADP-ribose transferase, and suffer from poor selectivity. PARP16, a mono-ADP-ribose tra...

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Detalles Bibliográficos
Autores principales:	Wang, Juanjuan, Zhu, Chenggang, Song, Dan, Xia, Ruiqi, Yu, Wenbo, Dang, Yongjun, Fei, Yiyan, Yu, Long, Wu, Jiaxue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502302/ https://www.ncbi.nlm.nih.gov/pubmed/28698806 http://dx.doi.org/10.1038/cddiscovery.2017.34

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