Tolerogenic insulin peptide therapy precipitates type 1 diabetes

Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified ins...

Descripción completa

Detalles Bibliográficos
Autores principales: Bergman, Marie-Louise, Lopes-Carvalho, Thiago, Martins, Ana-Catarina, Grieco, Fabio A., Eizirik, Décio L., Demengeot, Jocelyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502418/
https://www.ncbi.nlm.nih.gov/pubmed/28536239
http://dx.doi.org/10.1084/jem.20160471
_version_ 1783248952022269952
author Bergman, Marie-Louise
Lopes-Carvalho, Thiago
Martins, Ana-Catarina
Grieco, Fabio A.
Eizirik, Décio L.
Demengeot, Jocelyne
author_facet Bergman, Marie-Louise
Lopes-Carvalho, Thiago
Martins, Ana-Catarina
Grieco, Fabio A.
Eizirik, Décio L.
Demengeot, Jocelyne
author_sort Bergman, Marie-Louise
collection PubMed
description Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.
format Online
Article
Text
id pubmed-5502418
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-55024182018-01-03 Tolerogenic insulin peptide therapy precipitates type 1 diabetes Bergman, Marie-Louise Lopes-Carvalho, Thiago Martins, Ana-Catarina Grieco, Fabio A. Eizirik, Décio L. Demengeot, Jocelyne J Exp Med Letter Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis. The Rockefeller University Press 2017-07-03 /pmc/articles/PMC5502418/ /pubmed/28536239 http://dx.doi.org/10.1084/jem.20160471 Text en © 2017 Bergman et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Letter
Bergman, Marie-Louise
Lopes-Carvalho, Thiago
Martins, Ana-Catarina
Grieco, Fabio A.
Eizirik, Décio L.
Demengeot, Jocelyne
Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_full Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_fullStr Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_full_unstemmed Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_short Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_sort tolerogenic insulin peptide therapy precipitates type 1 diabetes
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502418/
https://www.ncbi.nlm.nih.gov/pubmed/28536239
http://dx.doi.org/10.1084/jem.20160471
work_keys_str_mv AT bergmanmarielouise tolerogenicinsulinpeptidetherapyprecipitatestype1diabetes
AT lopescarvalhothiago tolerogenicinsulinpeptidetherapyprecipitatestype1diabetes
AT martinsanacatarina tolerogenicinsulinpeptidetherapyprecipitatestype1diabetes
AT griecofabioa tolerogenicinsulinpeptidetherapyprecipitatestype1diabetes
AT eizirikdeciol tolerogenicinsulinpeptidetherapyprecipitatestype1diabetes
AT demengeotjocelyne tolerogenicinsulinpeptidetherapyprecipitatestype1diabetes

Ejemplares similares