Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression

Prolonged exit from quiescence by hematopoietic stem cells (HSCs) progressively impairs their homeostasis in the bone marrow through an unidentified mechanism. We show that Rb proteins, which are major enforcers of quiescence, maintain HSC homeostasis by positively regulating thrombopoietin (Tpo)-me...

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Detalles Bibliográficos
Autores principales: Kim, Eunsun, Cheng, Ying, Bolton-Gillespie, Elisabeth, Cai, Xiongwei, Ma, Connie, Tarangelo, Amy, Le, Linh, Jambhekar, Madhumita, Raman, Pichai, Hayer, Katharina E., Wertheim, Gerald, Speck, Nancy A., Tong, Wei, Viatour, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502420/
https://www.ncbi.nlm.nih.gov/pubmed/28550162
http://dx.doi.org/10.1084/jem.20160719

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