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Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization

The CXCL12/CXCR4 signaling exerts a dominant role in promoting hematopoietic stem and progenitor cell (HSPC) retention and quiescence in bone marrow. Gain-of-function CXCR4 mutations that affect homologous desensitization of the receptor have been reported in the WHIM Syndrome (WS), a rare immunodef...

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Detalles Bibliográficos
Autores principales:	Freitas, Christelle, Wittner, Monika, Nguyen, Julie, Rondeau, Vincent, Biajoux, Vincent, Aknin, Marie-Laure, Gaudin, Françoise, Beaussant-Cohen, Sarah, Bertrand, Yves, Bellanné-Chantelot, Christine, Donadieu, Jean, Bachelerie, Françoise, Espéli, Marion, Dalloul, Ali, Louache, Fawzia, Balabanian, Karl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502422/ https://www.ncbi.nlm.nih.gov/pubmed/28550161 http://dx.doi.org/10.1084/jem.20160806

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