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Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns

Recently, numerous compounds have been studied in order to develop antibacterial agents, which can prevent colonized wounds from infection, and assist the wound healing. For this purpose, novel silver chloride nanoparticles stabilized with chitosan oligomer (CHI-AgCl NPs) were synthesized to investi...

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Autores principales: Kang, Yun Ok, Jung, Ju-Young, Cho, Donghwan, Kwon, Oh Hyeong, Cheon, Ja Young, Park, Won Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502666/
https://www.ncbi.nlm.nih.gov/pubmed/28773340
http://dx.doi.org/10.3390/ma9040215
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author Kang, Yun Ok
Jung, Ju-Young
Cho, Donghwan
Kwon, Oh Hyeong
Cheon, Ja Young
Park, Won Ho
author_facet Kang, Yun Ok
Jung, Ju-Young
Cho, Donghwan
Kwon, Oh Hyeong
Cheon, Ja Young
Park, Won Ho
author_sort Kang, Yun Ok
collection PubMed
description Recently, numerous compounds have been studied in order to develop antibacterial agents, which can prevent colonized wounds from infection, and assist the wound healing. For this purpose, novel silver chloride nanoparticles stabilized with chitosan oligomer (CHI-AgCl NPs) were synthesized to investigate the influence of antibacterial chitosan oligomer (CHI) exerted by the silver chloride nanoparticles (AgCl NPs) on burn wound healing in a rat model. The CHI-AgCl NPs had a spherical morphology with a mean diameter of 42 ± 15 nm. The burn wound healing of CHI-AgCl NPs ointment was compared with untreated group, Vaseline ointment, and chitosan ointment group. The burn wound treated with CHI-AgCl NPs ointment was completely healed by 14 treatment days, and was similar to normal skin. Particularly, the regenerated collagen density became the highest in the CHI-AgCl NPs ointment group. The CHI-AgCl NPs ointment is considered a suitable healing agent for burn wounds, due to dual antibacterial activity of the AgCl NPs and CHI.
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spelling pubmed-55026662017-07-28 Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns Kang, Yun Ok Jung, Ju-Young Cho, Donghwan Kwon, Oh Hyeong Cheon, Ja Young Park, Won Ho Materials (Basel) Article Recently, numerous compounds have been studied in order to develop antibacterial agents, which can prevent colonized wounds from infection, and assist the wound healing. For this purpose, novel silver chloride nanoparticles stabilized with chitosan oligomer (CHI-AgCl NPs) were synthesized to investigate the influence of antibacterial chitosan oligomer (CHI) exerted by the silver chloride nanoparticles (AgCl NPs) on burn wound healing in a rat model. The CHI-AgCl NPs had a spherical morphology with a mean diameter of 42 ± 15 nm. The burn wound healing of CHI-AgCl NPs ointment was compared with untreated group, Vaseline ointment, and chitosan ointment group. The burn wound treated with CHI-AgCl NPs ointment was completely healed by 14 treatment days, and was similar to normal skin. Particularly, the regenerated collagen density became the highest in the CHI-AgCl NPs ointment group. The CHI-AgCl NPs ointment is considered a suitable healing agent for burn wounds, due to dual antibacterial activity of the AgCl NPs and CHI. MDPI 2016-03-23 /pmc/articles/PMC5502666/ /pubmed/28773340 http://dx.doi.org/10.3390/ma9040215 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Yun Ok
Jung, Ju-Young
Cho, Donghwan
Kwon, Oh Hyeong
Cheon, Ja Young
Park, Won Ho
Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns
title Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns
title_full Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns
title_fullStr Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns
title_full_unstemmed Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns
title_short Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns
title_sort antimicrobial silver chloride nanoparticles stabilized with chitosan oligomer for the healing of burns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502666/
https://www.ncbi.nlm.nih.gov/pubmed/28773340
http://dx.doi.org/10.3390/ma9040215
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