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Chiral Brønsted Acid‐Catalyzed Asymmetric Synthesis of N‐Aryl‐cis‐aziridine Carboxylate Esters

We report a multi‐component asymmetric Brønsted acid‐catalyzed aza‐Darzens reaction which is not limited to specific aromatic or heterocyclic aldehydes. Incorporating alkyl diazoacetates and, important for high ee's, ortho‐tert‐butoxyaniline our optimized reaction (i.e. solvent, temperature and...

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Detalles Bibliográficos
Autores principales:	Bew, Sean P., Liddle, John, Hughes, David L., Pesce, Paolo, Thurston, Sean M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502890/ https://www.ncbi.nlm.nih.gov/pubmed/28378388 http://dx.doi.org/10.1002/anie.201611990

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