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Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing
Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the ho...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502927/ https://www.ncbi.nlm.nih.gov/pubmed/28773385 http://dx.doi.org/10.3390/ma9040263 |
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author | Iacono, Marcello Connolly, Damian Heise, Andreas |
author_facet | Iacono, Marcello Connolly, Damian Heise, Andreas |
author_sort | Iacono, Marcello |
collection | PubMed |
description | Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths. |
format | Online Article Text |
id | pubmed-5502927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55029272017-07-28 Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing Iacono, Marcello Connolly, Damian Heise, Andreas Materials (Basel) Technical Note Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths. MDPI 2016-03-31 /pmc/articles/PMC5502927/ /pubmed/28773385 http://dx.doi.org/10.3390/ma9040263 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Technical Note Iacono, Marcello Connolly, Damian Heise, Andreas Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing |
title | Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing |
title_full | Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing |
title_fullStr | Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing |
title_full_unstemmed | Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing |
title_short | Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing |
title_sort | fabrication of a gma-co-edma monolith in a 2.0 mm i.d. polypropylene housing |
topic | Technical Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502927/ https://www.ncbi.nlm.nih.gov/pubmed/28773385 http://dx.doi.org/10.3390/ma9040263 |
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