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Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing

Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the ho...

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Detalles Bibliográficos
Autores principales: Iacono, Marcello, Connolly, Damian, Heise, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502927/
https://www.ncbi.nlm.nih.gov/pubmed/28773385
http://dx.doi.org/10.3390/ma9040263
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author Iacono, Marcello
Connolly, Damian
Heise, Andreas
author_facet Iacono, Marcello
Connolly, Damian
Heise, Andreas
author_sort Iacono, Marcello
collection PubMed
description Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths.
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spelling pubmed-55029272017-07-28 Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing Iacono, Marcello Connolly, Damian Heise, Andreas Materials (Basel) Technical Note Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths. MDPI 2016-03-31 /pmc/articles/PMC5502927/ /pubmed/28773385 http://dx.doi.org/10.3390/ma9040263 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Technical Note
Iacono, Marcello
Connolly, Damian
Heise, Andreas
Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing
title Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing
title_full Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing
title_fullStr Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing
title_full_unstemmed Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing
title_short Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing
title_sort fabrication of a gma-co-edma monolith in a 2.0 mm i.d. polypropylene housing
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502927/
https://www.ncbi.nlm.nih.gov/pubmed/28773385
http://dx.doi.org/10.3390/ma9040263
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