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Nanoparticles for Control of Biofilms of Acinetobacter Species
Biofilms are the cause of 80% of microbial infections. Acinetobacter species have emerged as multi- and pan-drug-resistant bacteria and pose a great threat to human health. These act as nosocomial pathogens and form excellent biofilms, both on biotic and abiotic surfaces, leading to severe infection...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503024/ https://www.ncbi.nlm.nih.gov/pubmed/28773507 http://dx.doi.org/10.3390/ma9050383 |
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author | Singh, Richa Nadhe, Shradhda Wadhwani, Sweety Shedbalkar, Utkarsha Chopade, Balu Ananda |
author_facet | Singh, Richa Nadhe, Shradhda Wadhwani, Sweety Shedbalkar, Utkarsha Chopade, Balu Ananda |
author_sort | Singh, Richa |
collection | PubMed |
description | Biofilms are the cause of 80% of microbial infections. Acinetobacter species have emerged as multi- and pan-drug-resistant bacteria and pose a great threat to human health. These act as nosocomial pathogens and form excellent biofilms, both on biotic and abiotic surfaces, leading to severe infections and diseases. Various methods have been developed for treatment and control of Acinetobacter biofilm including photodynamic therapy, radioimmunotherapy, prophylactic vaccines and antimicrobial peptides. Nanotechnology, in the present scenario, offers a promising alternative. Nanomaterials possess unique properties, and multiple bactericidal mechanisms render them more effective than conventional drugs. This review intends to provide an overview of Acinetobacter biofilm and the significant role of various nanoparticles as anti-biofouling agents, surface-coating materials and drug-delivery vehicles for biofilm control and treatment of Acinetobacter infections. |
format | Online Article Text |
id | pubmed-5503024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55030242017-07-28 Nanoparticles for Control of Biofilms of Acinetobacter Species Singh, Richa Nadhe, Shradhda Wadhwani, Sweety Shedbalkar, Utkarsha Chopade, Balu Ananda Materials (Basel) Review Biofilms are the cause of 80% of microbial infections. Acinetobacter species have emerged as multi- and pan-drug-resistant bacteria and pose a great threat to human health. These act as nosocomial pathogens and form excellent biofilms, both on biotic and abiotic surfaces, leading to severe infections and diseases. Various methods have been developed for treatment and control of Acinetobacter biofilm including photodynamic therapy, radioimmunotherapy, prophylactic vaccines and antimicrobial peptides. Nanotechnology, in the present scenario, offers a promising alternative. Nanomaterials possess unique properties, and multiple bactericidal mechanisms render them more effective than conventional drugs. This review intends to provide an overview of Acinetobacter biofilm and the significant role of various nanoparticles as anti-biofouling agents, surface-coating materials and drug-delivery vehicles for biofilm control and treatment of Acinetobacter infections. MDPI 2016-05-18 /pmc/articles/PMC5503024/ /pubmed/28773507 http://dx.doi.org/10.3390/ma9050383 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Singh, Richa Nadhe, Shradhda Wadhwani, Sweety Shedbalkar, Utkarsha Chopade, Balu Ananda Nanoparticles for Control of Biofilms of Acinetobacter Species |
title | Nanoparticles for Control of Biofilms of Acinetobacter Species |
title_full | Nanoparticles for Control of Biofilms of Acinetobacter Species |
title_fullStr | Nanoparticles for Control of Biofilms of Acinetobacter Species |
title_full_unstemmed | Nanoparticles for Control of Biofilms of Acinetobacter Species |
title_short | Nanoparticles for Control of Biofilms of Acinetobacter Species |
title_sort | nanoparticles for control of biofilms of acinetobacter species |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503024/ https://www.ncbi.nlm.nih.gov/pubmed/28773507 http://dx.doi.org/10.3390/ma9050383 |
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