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Nanoparticles for Control of Biofilms of Acinetobacter Species

Biofilms are the cause of 80% of microbial infections. Acinetobacter species have emerged as multi- and pan-drug-resistant bacteria and pose a great threat to human health. These act as nosocomial pathogens and form excellent biofilms, both on biotic and abiotic surfaces, leading to severe infection...

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Autores principales: Singh, Richa, Nadhe, Shradhda, Wadhwani, Sweety, Shedbalkar, Utkarsha, Chopade, Balu Ananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503024/
https://www.ncbi.nlm.nih.gov/pubmed/28773507
http://dx.doi.org/10.3390/ma9050383
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author Singh, Richa
Nadhe, Shradhda
Wadhwani, Sweety
Shedbalkar, Utkarsha
Chopade, Balu Ananda
author_facet Singh, Richa
Nadhe, Shradhda
Wadhwani, Sweety
Shedbalkar, Utkarsha
Chopade, Balu Ananda
author_sort Singh, Richa
collection PubMed
description Biofilms are the cause of 80% of microbial infections. Acinetobacter species have emerged as multi- and pan-drug-resistant bacteria and pose a great threat to human health. These act as nosocomial pathogens and form excellent biofilms, both on biotic and abiotic surfaces, leading to severe infections and diseases. Various methods have been developed for treatment and control of Acinetobacter biofilm including photodynamic therapy, radioimmunotherapy, prophylactic vaccines and antimicrobial peptides. Nanotechnology, in the present scenario, offers a promising alternative. Nanomaterials possess unique properties, and multiple bactericidal mechanisms render them more effective than conventional drugs. This review intends to provide an overview of Acinetobacter biofilm and the significant role of various nanoparticles as anti-biofouling agents, surface-coating materials and drug-delivery vehicles for biofilm control and treatment of Acinetobacter infections.
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spelling pubmed-55030242017-07-28 Nanoparticles for Control of Biofilms of Acinetobacter Species Singh, Richa Nadhe, Shradhda Wadhwani, Sweety Shedbalkar, Utkarsha Chopade, Balu Ananda Materials (Basel) Review Biofilms are the cause of 80% of microbial infections. Acinetobacter species have emerged as multi- and pan-drug-resistant bacteria and pose a great threat to human health. These act as nosocomial pathogens and form excellent biofilms, both on biotic and abiotic surfaces, leading to severe infections and diseases. Various methods have been developed for treatment and control of Acinetobacter biofilm including photodynamic therapy, radioimmunotherapy, prophylactic vaccines and antimicrobial peptides. Nanotechnology, in the present scenario, offers a promising alternative. Nanomaterials possess unique properties, and multiple bactericidal mechanisms render them more effective than conventional drugs. This review intends to provide an overview of Acinetobacter biofilm and the significant role of various nanoparticles as anti-biofouling agents, surface-coating materials and drug-delivery vehicles for biofilm control and treatment of Acinetobacter infections. MDPI 2016-05-18 /pmc/articles/PMC5503024/ /pubmed/28773507 http://dx.doi.org/10.3390/ma9050383 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Singh, Richa
Nadhe, Shradhda
Wadhwani, Sweety
Shedbalkar, Utkarsha
Chopade, Balu Ananda
Nanoparticles for Control of Biofilms of Acinetobacter Species
title Nanoparticles for Control of Biofilms of Acinetobacter Species
title_full Nanoparticles for Control of Biofilms of Acinetobacter Species
title_fullStr Nanoparticles for Control of Biofilms of Acinetobacter Species
title_full_unstemmed Nanoparticles for Control of Biofilms of Acinetobacter Species
title_short Nanoparticles for Control of Biofilms of Acinetobacter Species
title_sort nanoparticles for control of biofilms of acinetobacter species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503024/
https://www.ncbi.nlm.nih.gov/pubmed/28773507
http://dx.doi.org/10.3390/ma9050383
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