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The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration

This study introduces the effect of the thickness of a bacterial cellulose membrane by comparing the bone regeneration effect on rat skulls when using a collagen membrane and different thicknesses of resorbable bacterial cellulose membranes for guided bone regeneration. Barrier membranes of 0.10 mm,...

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Autores principales: Lee, You-Jin, An, Sung-Jun, Bae, Eun-Bin, Gwon, Hui-Jeong, Park, Jong-Seok, Jeong, Sung In, Jeon, Young-Chan, Lee, So-Hyoun, Lim, Youn-Mook, Huh, Jung-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503340/
https://www.ncbi.nlm.nih.gov/pubmed/28772680
http://dx.doi.org/10.3390/ma10030320
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author Lee, You-Jin
An, Sung-Jun
Bae, Eun-Bin
Gwon, Hui-Jeong
Park, Jong-Seok
Jeong, Sung In
Jeon, Young-Chan
Lee, So-Hyoun
Lim, Youn-Mook
Huh, Jung-Bo
author_facet Lee, You-Jin
An, Sung-Jun
Bae, Eun-Bin
Gwon, Hui-Jeong
Park, Jong-Seok
Jeong, Sung In
Jeon, Young-Chan
Lee, So-Hyoun
Lim, Youn-Mook
Huh, Jung-Bo
author_sort Lee, You-Jin
collection PubMed
description This study introduces the effect of the thickness of a bacterial cellulose membrane by comparing the bone regeneration effect on rat skulls when using a collagen membrane and different thicknesses of resorbable bacterial cellulose membranes for guided bone regeneration. Barrier membranes of 0.10 mm, 0.15 mm, and 0.20 mm in thickness were made using bacterial cellulose produced as microbial fermentation metabolites. Mechanical strength was investigated, and new bone formation was evaluated through animal experimental studies. Experimental animals were sacrificed after having 2 weeks and 8 weeks of recovery, and specimens were processed for histologic and histomorphometric analyses measuring the area of bone regeneration (%) using an image analysis program. In 2 weeks, bone-like materials and fibrous connective tissues were observed in histologic analysis. In 8 weeks, all experimental groups showed the arrangement of osteoblasts surrounding the supporting body on the margin and center of the bone defect region. However, the amount of new bone formation was significantly higher (p < 0.05) in bacterial cellulose membrane with 0.10 mm in thickness compared to the other experimental groups. Within the limitations of this study, a bacterial cellulose membrane with 0.10 mm thickness induced the most effective bone regeneration.
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spelling pubmed-55033402017-07-28 The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration Lee, You-Jin An, Sung-Jun Bae, Eun-Bin Gwon, Hui-Jeong Park, Jong-Seok Jeong, Sung In Jeon, Young-Chan Lee, So-Hyoun Lim, Youn-Mook Huh, Jung-Bo Materials (Basel) Article This study introduces the effect of the thickness of a bacterial cellulose membrane by comparing the bone regeneration effect on rat skulls when using a collagen membrane and different thicknesses of resorbable bacterial cellulose membranes for guided bone regeneration. Barrier membranes of 0.10 mm, 0.15 mm, and 0.20 mm in thickness were made using bacterial cellulose produced as microbial fermentation metabolites. Mechanical strength was investigated, and new bone formation was evaluated through animal experimental studies. Experimental animals were sacrificed after having 2 weeks and 8 weeks of recovery, and specimens were processed for histologic and histomorphometric analyses measuring the area of bone regeneration (%) using an image analysis program. In 2 weeks, bone-like materials and fibrous connective tissues were observed in histologic analysis. In 8 weeks, all experimental groups showed the arrangement of osteoblasts surrounding the supporting body on the margin and center of the bone defect region. However, the amount of new bone formation was significantly higher (p < 0.05) in bacterial cellulose membrane with 0.10 mm in thickness compared to the other experimental groups. Within the limitations of this study, a bacterial cellulose membrane with 0.10 mm thickness induced the most effective bone regeneration. MDPI 2017-03-21 /pmc/articles/PMC5503340/ /pubmed/28772680 http://dx.doi.org/10.3390/ma10030320 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, You-Jin
An, Sung-Jun
Bae, Eun-Bin
Gwon, Hui-Jeong
Park, Jong-Seok
Jeong, Sung In
Jeon, Young-Chan
Lee, So-Hyoun
Lim, Youn-Mook
Huh, Jung-Bo
The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration
title The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration
title_full The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration
title_fullStr The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration
title_full_unstemmed The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration
title_short The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration
title_sort effect of thickness of resorbable bacterial cellulose membrane on guided bone regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503340/
https://www.ncbi.nlm.nih.gov/pubmed/28772680
http://dx.doi.org/10.3390/ma10030320
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