Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus

On the basis of our prior structure-activity relationship (SAR) results, our current lead optimization of 1,5-diarylanilines (DAANs) focused on the 4-substituent (R(1)) on the central phenyl ring as a modifiable position related simultaneously to improved drug resistance profiles and drug-like prope...

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Detalles Bibliográficos
Autores principales: Wei, Lei, Wang, Hui-Ling, Huang, Li, Chen, Chin-Ho, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Xie, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503476/
https://www.ncbi.nlm.nih.gov/pubmed/28465101
http://dx.doi.org/10.1016/j.bmcl.2017.04.068

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