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Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells

Understanding cancer stem cell (CSC) maintenance pathways is critical for the development of CSC-targeting therapy. Here, we investigated the functional role of the cyclin D1-dependent activation of Smad2/3 and Smad4 in hepatocellular carcinoma (HCC) CSCs and in HCC primary tumors. Cyclin D1 sphere-...

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Detalles Bibliográficos
Autores principales:	Xia, Wei, Lo, Chung Mau, Poon, Randy Y.C., Cheung, Tan To, Chan, Albert C.Y., Chen, Lin, Yang, Sitian, Tsao, George S.W., Wang, Xiao Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503574/ https://www.ncbi.nlm.nih.gov/pubmed/28415588 http://dx.doi.org/10.18632/oncotarget.16402

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