The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells

Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs that might affect Lung adenocarcinoma (LAD) chemo-resistance and most of them could be used as biomarkers and therapy targets. However, the potential function of lncRNA ANRIL contributed paclitaxel chemo-resistance in LAD is stil...

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Autores principales: Xu, Ran, Mao, Yuqiang, Chen, Kuanbing, He, Wei, Shi, Wenjun, Han, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503604/
https://www.ncbi.nlm.nih.gov/pubmed/28402932
http://dx.doi.org/10.18632/oncotarget.16640
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author Xu, Ran
Mao, Yuqiang
Chen, Kuanbing
He, Wei
Shi, Wenjun
Han, Yun
author_facet Xu, Ran
Mao, Yuqiang
Chen, Kuanbing
He, Wei
Shi, Wenjun
Han, Yun
author_sort Xu, Ran
collection PubMed
description Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs that might affect Lung adenocarcinoma (LAD) chemo-resistance and most of them could be used as biomarkers and therapy targets. However, the potential function of lncRNA ANRIL contributed paclitaxel chemo-resistance in LAD is still unknown. This study aimed to observe the expression of ANRIL in LAD, evaluate its biological role in the resistance of LAD cells to paclitaxel and explore the apoptosis role in the ANRIL associated mechanism. Our results showed that ANRIL functioning as a potential oncogene was up-regulated in LAD, and promoted the acquisition of chemo-resistance in paclitaxel partly through the mitochondrial pathway by modulating the expression of apoptosis-related protein cleaved-PARP and Bcl-2. These findings might improve LAD patients' paclitaxel treatment and made ANRIL to be a new target for paclitaxel-based chemotherapy in LAD.
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spelling pubmed-55036042017-07-11 The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells Xu, Ran Mao, Yuqiang Chen, Kuanbing He, Wei Shi, Wenjun Han, Yun Oncotarget Research Paper Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs that might affect Lung adenocarcinoma (LAD) chemo-resistance and most of them could be used as biomarkers and therapy targets. However, the potential function of lncRNA ANRIL contributed paclitaxel chemo-resistance in LAD is still unknown. This study aimed to observe the expression of ANRIL in LAD, evaluate its biological role in the resistance of LAD cells to paclitaxel and explore the apoptosis role in the ANRIL associated mechanism. Our results showed that ANRIL functioning as a potential oncogene was up-regulated in LAD, and promoted the acquisition of chemo-resistance in paclitaxel partly through the mitochondrial pathway by modulating the expression of apoptosis-related protein cleaved-PARP and Bcl-2. These findings might improve LAD patients' paclitaxel treatment and made ANRIL to be a new target for paclitaxel-based chemotherapy in LAD. Impact Journals LLC 2017-03-29 /pmc/articles/PMC5503604/ /pubmed/28402932 http://dx.doi.org/10.18632/oncotarget.16640 Text en Copyright: © 2017 Xu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Xu, Ran
Mao, Yuqiang
Chen, Kuanbing
He, Wei
Shi, Wenjun
Han, Yun
The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells
title The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells
title_full The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells
title_fullStr The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells
title_full_unstemmed The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells
title_short The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells
title_sort long noncoding rna anril acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma a549 cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503604/
https://www.ncbi.nlm.nih.gov/pubmed/28402932
http://dx.doi.org/10.18632/oncotarget.16640
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